Could this disgusting fruit fight cancer?In the future, the drug resistance problem is expected to be overcome

2022-05-13 0 By

Please click on the “attention” before reading, regularly send health related articles every day, to find health care health information with you ~ recently, international journal of Cancer Discovery, a new study found that [1], a kind of fruit from distant and mysterious continent of South America, may enhance the curative effect of immunotherapy, and to overcome its resistance,To aid in immunotherapy.This fruit is the “queen of fruit” of the Andes, the Camu Camu.Because of its surprisingly high vitamin C content, it is mainly used as a skin care ingredient in the beauty world.In the latest study, how does the fruit queen exert its anti-cancer effects?Surprisingly, it’s not vitamin C, the famous ingredient, but another natural antioxidant, a polyphenol called castalagin, which is found not only in camberries but also in other foods such as guava.The gut microbiota is the key to immunotherapy resistance and the advent of immunotherapy has literally turned the tables on cancer treatment.In the past, cancer treatment has focused on developing “bullets” that can accurately strangle cancer cells, i.e. drugs that can directly attack cancer cells.But what we seem to be missing is the immune system itself, which can carry a gun against cancer cells.In fact, the birth of immunotherapy is that scientists have strengthened the training of the immune system, which “carries the gun”, encouraging the morale of the immune soldiers in the body of cancer patients, so that the immune system can “charge” more accurately to kill cancer cells.Many studies have also proved that immunotherapy improves the overall survival rate of many patients with advanced cancer [2-4].However, the occurrence of drug resistance of PD-1 inhibitors, known as “anti-cancer miracle drugs”, is still a headache.There are many reasons for resistance to immunotherapy.Among them, because the intestinal flora is closely related to the immune system, some studies believe that the stability and richness of intestinal flora may determine the efficacy of immunotherapy and also affect the occurrence of immunotherapy resistance [5].Nowadays, many studies have found that improving intestinal flora can indeed help immunotherapy [6, 7].Kamm fruit through the mediation of intestinal flora to overcome before immune treatment resistant studies have shown that [8], kamm fruit of a variety of plant chemicals, can increase the abundance of intestinal flora in mice, thus inhibiting visceral fat, such as liver fat accumulation, and increase the consumption of energy, the obesity and related metabolic disorders in mice have prebiotics protective effects.Because gut microbiota is also linked to immune system function, scientists wondered if using camberries to improve this property could help with immunotherapy.So they did a similar study in mice.[1] It was found that the combination therapy with αPD-1 (anti-PD-1 antibody) showed a significant inhibitory effect on tumor growth.The study also confirmed that the anti-cancer effects of camfruit may depend on the intestinal flora of mice.Researchers analyzed its reason, perhaps because of kamm fruit called a chestnut ellagic element of polyphenols, through associated with rumen bacteria, which affect the CD8 + T cells (immune system is a critical part of) the mediating role of, to adjust the intestinal flora, play a promote immune system responses, to overcome the immunotherapy drug resistance, and so on.If the gut microbiota is the “bridge” between immune drugs and the immune system, then chestnut ellagin may be helping to repair or even build the bridge.The implications of this study are significant, and it is possible that in the near future, chestnut ellagins in camfruit could be used as an adjunct to immunotherapy to help cancer patients achieve better outcomes and thus longer survival.Can camberries now help boost immunotherapy by eating them?Kopjun’s advice is to taste the fruit, but the anti-cancer effects of camfruit have not yet been tested in human clinical trials, and it is not certain that the effects in mice will be replicated in humans.Also, the fruit may not be available for purchase.The fruit is mostly found in the Amazon rainforest and was initially unknown to the local population.However, as its high levels of natural vitamin C are becoming known, it is slowly becoming a superfood.And the important thing is, camberries aren’t really tasty.Although it has a purplish red skin and yellow flesh, it is small and looks very much like a grape.Underneath the grape, though, the taste is tart and astringent, like lemon.It’s like a lemon in a grape skin, so to speak.Why are camberries so sour?It’s because we can eat camberries, which are not fully ripe.By the time the fruit is fully ripe, not only can it not be stored well, its vitamin C content is also greatly reduced.So, basically, only the local people where the fruit is grown can eat the fruit when it is fully ripe.But it’s not just the camberries that contain the polyphenols. Guava, sea buckthorn and even chestnuts contain some of it, though not as much as camberries.Conclusion As we all know, fruit is a nutritious food, and the dietary guidelines recommend that each person should eat about 300 grams of fruit every day, and it should be as varied as possible [9].Additional, also have a lot of research discovery, a lot of fruits have certain anticancer effect, tumor patient should pay attention to the intake of fruit more.However, we should not over-deify the role of fruit, or even over-superstitious fruit anti-cancer efficacy.At the same time, do not excessive diet, most fruits, as long as the right amount to eat every day, in fact, can be assured to eat.Find friends also want to know which fruits can not eat, or which fruits to eat more beneficial, you can ask questions in the message area oh ~ related links: lung cancer targeted treatment must avoid fruit!References:[1]Messaoudene M, Pidgeon R, Richard C, et al. A natural polyphenol exerts antitumor activity and circumvents anti-PD-1 resistance through effects on the gut microbiota [published online ahead of print, 2022 Jan 14]. Cancer Discov. 2022;Candisc.0808.2021. doi:10.1158/2159-8290.CD-21-0808[2]Gandhi L, Rodriguez-Abreu D, Gadgeel S,et al. Pembrolizumab plus Chemotherapy in Metastatic Non-Small-Cell Lung Cancer. N Engl J Med. 2018;378 (22) : 2078-2092. The doi: 10.1056 / NEJMoa1801005 [3] Motzer RJ, Tannir NM, McDermott DF,et al. Nivolumab plus Ipilimumab versus Sunitinib in Advanced Renal-Cell Carcinoma. N Engl J Med. 2018;378 (14) : 1277-1290. The doi: 10.1056 / NEJMoa1712126 [4] Elkrief A, Joubert P, Florescu M, Tehfe M, Blais N,Routy B. Therapeutic landscape of metastatic non-small-cell lung cancer in Canada in 2020. Curr Oncol. 2020;Doi :10.3747/ CO.27.5953 [5]Routy B, Gopalakrishnan V, Daillere R, Zitvogel L, Wargo JA,Kroemer G. The gut microbiota influences anticancer immunosurveillance and general health. Nat Rev Clin Oncol. 2018;Doi :10.1038/ S41571-018-0006-2 [6]Davar D, Dzutsev AK, McCulloch JA, et al.et al. Fecal microbiota transplant overcomes resistance to anti-PD-1 therapy in melanoma patients. Science. 2021;371 (6529) : 595-602. The doi: 10.1126 / science abf3363 [7] Jin Y, Dong H, Xia L,et al. The Diversity of Gut Microbiome is Associated With Favorable Responses to Anti-Programmed Death 1 Immunotherapy in Chinese Patients With NSCLC. J Thorac Oncol. 2019;14 (8) : 1378-1389. The doi: 10.1016 / j.j. Tho 2019.04.007 [8] Anhe FF, Nachbar RT, adding that TV,et al. Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice. Gut. 2019;Doi :10.1136/ GUTJNL-2017-315565 [9] Wang J, Wang J, Wang J, et al.Scientific Research Report on Dietary Guidelines for Chinese Residents (2021). National Health, Author: Mi Jian kopjun Responsible editor: MI Jian Kopjun cover photo source: Tuworm Creativity